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ea0092op-12-03 | Oral Session 12: Emerging Insights into Thyroid Cancer Genetics | ETA2023

Different histological variants in multifocal PTC analyzed by NGS show an independent molecular origin

Ramone Teresa , Ciampi Raffaele , Romei Cristina , Casalini Roberta , Almeida Jacqueline , Minaldi Elisa , Ugolini Clara , Signorini Francesca , Basolo Fulvio , Elisei Rossella

Objective: Currently, data about the molecular profile of multifocal papillary thyroid cancer (PTC) are still controversial. The aim of this study was to fully characterize by NGS the molecular profile of different histological variants in patients affected by multifocal PTCs.Methods: for this purpose, 12 multifocal PTC patients have been studied based to the following inclusion criteria: 1) a minimum of two tumors foci per patient with at least two diff...

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ea0092ps3-28-03 | Translational 2 | ETA2023

Molecular analysis of multiple foci of sporadic medullary thyroid carcinoma suggests that they are intrathyroidal metastases from the same primary tumor

Almeida Jacqueline , Ciampi Raffaele , Casalini Roberta , Ramone Teresa , Mori Sara , Cappagli Virginia , Materazzi Gabriele , Ugolini Clara , Basolo Fulvio , Ward Laura , Elisei Rossella , Romei Cristina

Sporadic medullary thyroid cancer (sMTC) presents mutations of the RET proto-oncogene in about 50% of the cases and of the RAS proto-oncogene in about 20% of the cases. In about 15% of cases, sMTC is multifocal and it is not known whether multiple foci can be considered as intrathyroidal metastases of the main tumor focus or if they can be considered as independent tumors. To clarify this issue, we examined the mutation profile of multiple intrathyroidal tumo...

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Endocrine Abstracts

Different histological variants in multifocal PTC analyzed by NGS show an independent molecular origin

Molecular analysis of multiple foci of sporadic medullary thyroid carcinoma suggests that they are intrathyroidal metastases from the same primary tumor

BiosciAbstracts